All materials are included with permission. The opinions expressed are those of the faculty and are not to be construed as those of the publisher.

This educational activity was planned and produced in accordance with the ACCME Accreditation Criteria, Policies and Standards for Commercial Support. Recommendations involving clinical medicine in a Continuing Medical Education (CME/CE) activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME/CE in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection and analysis.

This CME/CE activity might describe the off-label, investigational or experimental use of medications that may exceed their FDA- approved labeling. Physicians should consult the current manufacturers’ prescribing information for these products. RUSH University Medical Center requires the speaker to disclose that a product is not labeled for the use under discussion.

ACTIVITY EN332-1021

Biofluid biomarkers have established value in predicting cognitive and functional decline. However, their cross-sectional and longitudinal associations with neuropsychiatric symptoms are widely unknown. Biological predictors of neuropsychiatric syndromes may be useful for diagnostic and therapeutic strategies for dementia. Conversely, neuropsychiatric syndromes may also serve as proxy markers for neuropathological change.

Upon completion of this course, participants will be able to:

• Critically analyze the neurobiological underpinnings of cerebrospinal biomarker changes across the lifespan and in pathological conditions.
• Describe the associations between cerebrospinal biomarkers with neuropsychiatric features and cognitive changes in patients across the cognitive continuum.
• Determine and evaluate the biological variants that may lead to the development of diverse neuropsychiatric syndromes in different patients.​ 

This curriculum will take approximately 60 minutes to complete. To receive maximum credit, participants are required to view the presentation in its entirety. Upon completion of the activity and evaluation form, a certificate will be immediately available. There is no fee to participate in the activity or for the generation of the certificate.

For questions, contact clinicaledu@alz.org. 

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE) and the American Nurses Credentialing Center (ANCC) to provide continuing education for the health care team.

Rush University Medical Center designates this internet enduring material activity for a maximum of one (1) AMA PRA Category 1 Credit™. Physicians should claim only credit commensurate with the extent of their participation in the activity. This activity is being presented without bias and with commercial support.

Rush University Medical Center designates this activity for one (1) CE credit in psychology. This activity is being presented without bias and with commercial support.

Disclosures

Faculty reports the following relationship(s)

• Dr. de Oliveira discloses that he is a consultant to Gerson Lehrman Group, Atheneum Partners, Guidepoint, Health Advances and Lionbridge;
• Dr. Fischer discloses that she has a research grant from Vielight Inc., Hoffman La Roche, Cortexyme;
• Dr. Ismail has no relevant financial disclosures;
• Dr. Tarawneh has no relevant financial disclosures;

The remaining course director(s), planner(s), faculty and reviewer(s) of this activity have no relevant financial relationships to disclose.

Hardware and Software Requirements

1. Active internet connection (DSL or Cable). Dial-up connection will have constant buffering problems while viewing any media (audio/video).
2. Compatible with Windows PC and MAC (256 MB of RAM or higher)
   
   • Windows OS 7.0 and higher.
   • MAC OS “Mountain Lion” and higher.
3. Activity is best viewed on Internet Explorer 9.0 or higher, Safari 5.0 or higher and Firefox 40.0 or higher
4. Peripherals: Speakers for audio.
5. Adobe Reader to print certificate. Click here to download Adobe Reader for free.