Down Syndrome and Alzheimer's Disease: Understanding Alzheimer’s disease development in the context of Down syndrome; using preclinical models

Recorded: May 26, 2021

Individuals who have Down syndrome have a greatly elevated risk of early-onset Alzheimer’s disease. We use Down syndrome mouse models to understand the combination of chromosome 21 genes that modulate aspects of AD pathogenesis when in three-copies, including the formation and accumulation of amyloid-β.

Moderators: Sigan Hartley, Michael Rafii

Panelist: Frances Wiseman