Down Syndrome and Alzheimer’s Disease PIA: Precocious microglia and novel RNA diversity from single cell studies of the aging, human Down syndrome (DS) brain

Recorded: February 2, 2022

The single-cell RNA landscape of the aging DS brain (PNAS 2021 e2114326118) identifies early microglial activation with new RNA diversity affecting the Alzheimer’s and DS gene APP and more that may reflect somatic gene recombination in the DS brain

Moderator: Michael Rafii

Panelist: Jerold Chun