Down Syndrome and Alzheimer’s Disease PIA: Sleep and Alzheimer's Disease in Down Syndrome

Recorded: April 20, 2022

The prevalence of sleep disruptions and sleep disordered breathing based on objective measures (actigraphy & WatchPAT) in adults with Down Syndrome and their relation to biomarkers of Alzheimer's pathology and symptomology (dementia symptoms and cognitive performance) are discussed. Cross-sectional associations among obstructive sleep apnea (OSA), MRI-based markers of cerebrovascular disease, and Alzheimer’s disease (AD) diagnosis suggest that OSA treatment may improve cerebrovascular outcomes during AD progression for adults with Down syndrome.

Moderators: Sigan Hartley, Michael Rafii

Panelists: Tori Fleming, Patrick J. Lao