All materials are included with permission. The opinions expressed are those of the faculty and are not to be construed as those of the publisher.

This educational activity was planned and produced in accordance with the ACCME Accreditation Criteria, Policies and Standards for Commercial Support. Recommendations involving clinical medicine in a Continuing Medical Education (CME/CE) activity must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in CME/CE in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection and analysis.

This CME/CE activity might describe the off-label, investigational or experimental use of medications that may exceed their FDA- approved labeling. Physicians should consult the current manufacturers’ prescribing information for these products. RUSH University Medical Center requires the speaker to disclose that a product is not labeled for the use under discussion.

The purpose of this webinar is to enhance knowledge on the potential use of biofluid biomarkers to assess neuropsychiatric diagnoses and drug response in dementia with Lewy bodies as well as in preclinical and prodromal Alzheimer's disease.

ACTIVITY - EN514-0223

Upon completion of this webinar you will learn:

1. To discuss associations of biofluid biomarkers with neuropsychiatric symptoms in all stages of dementia with Lewy bodies.
2. To establish potential associations of emerging plasma biomarkers of tauopathy with neuropsychiatric symptoms in preclinical and prodromal Alzheimer's disease.
3. To investigate if biofluid biomarkers of neuropsychiatric syndromes can be used to assess therapeutic drug response in different stages of neurodegenerative diseases.
4. To discuss advantages and disadvantages of plasma and cerebrospinal fluid biomarkers for research and clinical correlations.
5. To critically analyze the neurobiological underpinnings of biofluid biomarker changes in pathological conditions leading to the
   development of diverse neuropsychiatric syndromes in different patients.

This curriculum will take approximately 60 minutes to complete. To receive maximum credit, participants are required to view the presentation in its entirety. Upon completion of the activity and evaluation form, a certificate will be immediately available. There is no fee to participate in the activity or for the generation of the certificate.

For questions, contact clinicaledu@alz.org 

In support of improving patient care, Rush University Medical Center is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

For Medicine:

Rush University Medical Center designates enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

For Psychologists:

Rush University Medical Center designates this enduring material for 1.00 CE credits in psychology.

Disclosures - Faculty reports the following relationship(s)

Dr. Fabricio Ferreira de Oliveira has disclosed consultancies to Gerson Lehrman Group - GLG, Atheneum Partners, Guidepoint, and Lionbridge. He is also Associate Editor (paid) of Clinical Neurology & Neurosurgery (Elsevier), Associate Editor (unpaid) of Frontiers in Neuroscience (Frontiers Media) and the Journal of Alzheimer's Disease (IOS Press), Academic Editor (unpaid) of Medicine (Wolters Kluwer Health).

Dr. Zahinoor Ismail has disclosed consultancies to Acadia, Biogen, Roche - paid to institution; Lundbeck/Otsuka - paid personally

Dr. Fabrizia D'Antonio has no relevant financial disclosures;

Dr. Maryam Ghahremani has no relevant financial disclosures;

Dr. Claire Sexton, Alzheimer’s Association staff, has no relevant financial disclosures.

1. Active internet connection (DSL or Cable). Dial-up connection will have constant buffering problems while viewing any media (audio/video).